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  • Organisation
    a national and international basis if reasonable and manageable All technical conditions for the development of these repositories and the secure asservation of samples are fulfilled and standard operation procedures SOPs for conservation splitting and conditioning of the material are available Software solutions which permit interrogation and logical connection of this data were developed in previous activities in NGFN networks All tissue banks aim for a connection with corresponding data banks registers with a detailed clinical characterization and to follow the individual course of disease The extension for following bio banks is scheduled Human primary lung cell banks These involve alveolar an bronchial epithelial cells macro and micro vascular endothelial cells pulmonary vascular fibroblasts pulmonary vascular smooth muscle cells and interstitial lipo and myofibroblasts from healthy donor lungs plus lungs of patients with pulmonary hypertension lung fibrosis and COPD emphysema cooperation with the EU projects Pulmotension and eurIPFnet extensive cell banks are already partly available Blood cell bank at pneumonia and pneumogene sepsis This involves a collection of 1 000 very well characterized samples obtained at defined time points after the beginning of pneumonia or rather sepsis cooperation with the NGFN net infection and inflammation plus CAPNetz SEPNET and PROGRESS Broncho alveolar lavage bank in ARDS mandatory ventilation pneumonia and different forms of ILD This includes at the moment 900 samples which were asservated over a period of 6 years Blood cell and plasma serum bank in pulmonary hypertension This includes a collection of 2 000 patients with apparent pulmonary hypertension of different etiologies which were built up over a period of 10 years The samples are cataloged in the data bank for PH patients in Giessen biggest mono centric data bank of the world Stem Progenitor cell bank Bank for human progenitor and stem cells out of the blood

    Original URL path: http://www.ugmlc.de/index.php?id=139 (2016-02-17)
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  • Areas of Research - A Inflammation
    disease as well as new therapeutic approaches Thus this work program is distinguished from other consortia in the region like the SFB TR22 The SFB TR22 focuses on the initiation of the allergic immune response the pre and postnatal immune programming including complex gene environment interaction as well as allergic phenotypes Faculty members involved Bauer S Bellusci Braun Chakraborty Dammann Domann Fink Garn Gessler Grau Grimminger Günther Henke Hossain Huber Koczulla Kracht Kummer Nassenstein Nockher Pfefferle Renz Schermuly Schmeck Schmitz Schnare Seifart Sittka Steinhoff Vogelmeier Voswinckel Weihe Weißmann Wilhelm Wygrecka Zemlin Specific Projects Perpetuation of the disease process in asthma and COPD role of the cell biological network Neuronal dysfunction in asthma and COPD Shared an differential signaling pathways in the pathogenesis of asthma and COPD Remodeling and fibrosis regeneration in asthma and COPD Chronic inflammatory lung diseases as systemic diseases Novel therapeutic strategies in asthma and COPD Pneumonia The main research goal in this funding period in addition to the further mechanistic elucidation of the pathogen host interaction in the pneumonic inflammatory process is the preclinical clinical evaluation of identified mediators target structures for therapeutic intervention strategies Investigations will be carried out in murine and human organ cell cultures and lung models in vivo pneumonia models of bacterial viral pathogens as well as in clinical samples blood sputum BALF of patient cohorts Potential targets and intervention strategies to be evaluated are 1 the cell specific function of sensors for pathogen host coded danger signals TLR NLR RLH including downstream signal transduction 2 the molecular pathways of pulmonary leukocyte recruiting 3 resolvins and anti apoptosis strategies to limit tissue damage 4 growth factors e g GM CSF for lung resident stem progenitor cells and cell therapeutic approaches e g intratracheally applied mesenchymal stem cells to stimulate repair mechanisms and 5

    Original URL path: http://www.ugmlc.de/index.php?id=141 (2016-02-17)
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  • Areas of Research - B Hyperproliferation
    monoxide NO soluble guanylate cyclase phoshodiesterase axis in experimental right heart hypertrophy Role of microRNAs in pulmonary hypertension Controlled release formulations to optimize inhalative therapy Lung fibrosis Rampant apoptosis of alveolar type II cells AECII is in the focus of the pathogenetic sequence of a number of fibrotic lung diseases idiopathic pulmonary fibrosis IPF among them Accordingly we will investigate the causes for development of endoplasmic reticulum ER stress lysosomal stress and DNA damage as main triggers of increased apoptosis of the alveolar epithelium Another focus will be on epithelial progenitor cells their cellular origin molecular marker profile and regenerative capacity in models of lung fibrosis and lung development below the kidney capsule Our working hypothesis states that progenitor cells in IPF lungs have a drastically reduced regenerative capacity and that this is reflected by surrogate markers of aging at the cellular level shortening of telomeres ER stress ROS Regarding the execution of the fibrotic response we will investigate the role of the intrinsic alveolar clotting system FoxO transcription factors and fibroblast growth factors FGF In addition we will analyze which progenitor cells feed the expanding myofibroblast pool Finally the role of genetic changes in the fixation of the pro fibrotic phenotype will analyzed Overall the outlined activities will follow a translational therapeutically aligned approach molecular interventions will be tested in pre clinical studies and developed using latest technologies e g in vivo imaging for apoptosis These approaches will be integrated into current and planned clinical trials in proof of concept and up to phaseII III studies Faculty members involved Barreto Bellusci Braun Fink Günther Hackstein Herold Lohmeyer Markart Matrosovich Morty Müller Ladner Preissner Pullamsetti Renz Schermuly Schmeck Seeger Seifart Stainier Voswinckel Vogelmeier Wilhelm Wygrecka Specific Proje cts Chronic damage to the alveolar epithelium by disturbed intracellular processing of surfactant

    Original URL path: http://www.ugmlc.de/index.php?id=142 (2016-02-17)
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  • Publications
    T MacRae CA Stainier DYR Poss KD Primary contribution to zebrafish heart regeneration by Gata4 cardiomyocytes Nature 464 601 605 2010 IF 36 1 37 Kleinschnitz C Weissmann N Schmidt HH Post stroke inhibition of induced NADPH oxidase type 4 prevents oxidative stress and neurodegeneration PLoS Biol 8 e1000479 2010 IF 12 5 38 Kneidinger N Yildirim AÖ Callegari J Takenaka S Stein MM Dumitrascu R Bohla A Bracke KR Morty RE Brusselle GG Schermuly RT Eickelberg O Königshoff M Activation of the WNT β catenin pathway attenuates experimental emphysema Am J Respir Crit Care Med 183 723 733 2011 IF 10 2 39 Kubin T Poling J Kostin S Gajawada P Hein S Rees W Wietelmann A Tanaka M Lorchner H Schimanski S Szibor M Warnecke H Braun T Oncostatin m is a major mediator of cardiomyocyte dedifferentiation and remodeling Cell Stem Cell 9 420 432 2011 IF 25 9 40 Kumari A Brendel C Hochhaus A Neubauer A Burchert A Low BCR ABL expression levels in hematopoietic precursor cells enable persistence of chronic myeloid leukemia under imatinib Blood 119 530 539 2012 IF 10 6 41 Lommatzsch M Kummer W Virchow JC Bronchoconstriction and airway remodeling Letter to Effect of methacholine and albuterol on airway remodeling in asthma New Engl J Med 365 1156 1157 2011 IF 53 5 42 Lukasova M Hanson J Tunaru S Offermanns S Nicotinic acid niacin new lipid independent mechanisms of action and therapeutic potential Trends Pharmacol Sci 32 700 707 2011 IF 11 1 43 Lukasova M Malaval C Gille A Kero J Offermanns S Nicotinic acid inhibits progression of atherosclerosis in mice through its receptor GPR109A expressed by immune cells J Clin Invest 121 1163 1173 2011 IF 14 2 44 Mahavadi P Korfei M Henneke I Liebisch G Schmitz G Gochuico BR Markart P Bellusci S Seeger W Ruppert C Guenther A Epithelial stress and apoptosis underlie Hermansky Pudlak syndrome associated interstitial pneumonia Am J Respir Crit Care Med 182 207 219 2010 IF 10 2 45 Markart P Wygrecka M Guenther A Update in diffuse parenchymal lung disease 2010 Am J Respir Crit Care Med 183 1316 1321 2011 IF 10 2 46 Massberg S Preissner KT Engelmann B Reciprocal coupling of coagulation and innate immunity via neutrophil serine proteases Nature Med 16 887 896 2010 IF 25 4 47 McLaughlin VV Benza RL Rubin LJ Channick RN Voswinckel R Tapson VF Robbins IM Olschewski H Rubenfire M Seeger W Addition of Inhaled Treprostinil to Oral Therapy for Pulmonary Arterial Hypertension A Randomized Controlled Clinical Trial J Am Coll Cardiol 55 1915 1922 2010 IF 14 3 48 Mercier JC Zemlin M Edner A Inhaled nitric oxide for prevention of bronchopulmonary dysplasia in premature babies EUNO a randomised controlled trial Lancet 376 346 354 2010 IF 33 6 49 Morty RE Targeting elastase in bronchopulmonary dysplasia Am J Respir Crit Care Med 184 496 497 2011 IF 10 191 50 Neumann E Lefèvre S Zimmermann B Gay S Müller Ladner U Rheumatoid arthritis progression mediated by activated synovial fibroblasts Trends Mol Med 16 458 468 2010 IF 10 3 51 Neves P Lampropoulou V Calderon Gomez E Roch T Stervbo U Shen P Kühl A Loddenkemper C Haury M Nedospasov S Kaufmann SHE Steinhoff U Calado D Fillatreau S MyD88 signalling in B cells suppresses protective immunity during Salmonella typhimurium infection Immunity 33 777 790 2010 IF 24 2 52 Offermanns S Colletti SL Lovenberg TW Semple G Wise A Ijzerman AP International Union of Basic and Clinical Pharmacology LXXXII Nomenclature and Classification of Hydroxy carboxylic Acid Receptors GPR81 GPR109A and GPR109B Pharmacol Rev 63 269 290 2011 IF 18 861 53 Pfeifer GP Dammann RH Tommasi S RASSF proteins Curr Biol 20 344 2010 IF 10 0 54 Pleines I Hagedorn I Gupta S May F Chakarova L van Hengel J Offermanns S Krohne G Kleinschnitz C Brakebusch C Nieswandt B Megakaryocyte specific RhoA deficiency causes macrothrombocytopenia and defective platelet activation in hemostasis and thrombosis Blood epub ahead of print 2011 IF 10 6 55 Poeling J Szibor M Kubin T Rees W Loerchner H Gajawada P Warnecke H Braun T The ras related protein rap2 is part of the fibroblast growth factor 2 initiated arteriogenic program in growing collateral vessels Eur Heart J 31 621 622 2010 IF 10 1 56 Prinz N Clemens N Strand D Putz I Lorenz M Daiber A Stein P Degreif A Radsak M Schild H Bauer S von Landenberg P Lackner KJ Antiphospholipid antibodies induce translocation of TLR7 and TLR8 to the endosome in human monocytes and plasmacytoid dendritic cells Blood 118 2322 2332 2011 IF 10 6 57 Pullamsetti SS Doebele C Fischer A Savai R Kojonazarov B Dahal BK Ghofrani HA Weissmann N Grimminger F Bonauer A Seeger W Zeiher AM Dimmeler S Schermuly RT Inhibition of microRNA 17 Improves Lung and Heart Function in Experimental Pulmonary Hypertension Am J Respir Crit Care Med 185 409 419 2012 IF 10 2 58 Pullamsetti SS Savai R Schaefer MB Wilhelm J Ghofrani HA Weissmann N Schudt C Fleming I Mayer K Leiper J Seeger W Grimminger F Schermuly RT cAMP phosphodiesterase inhibitors increases nitric oxide production by modulating dimethylarginine dimethylaminohydrolases Circulation 123 1194 1204 2011 IF 14 4 59 Randriamboavonjy V Isaak J Frömel T Viollet B Fisslthaler B Preissner KT Fleming I The AMP activated protein kinase AMPK a2 subunit is involved in platelet signaling clot retraction and thrombus stability Blood 116 2134 2140 2010 IF 10 6 60 Renner F Moreno R Schmitz ML SUMOylation dependent localization of IKKe in PML nuclear bodies is essential for protection against DNA damage triggered cell death Mol Cell 37 503 515 2010 IF 14 2 61 Renz H Brandtzaeg P Hornef M The impact of perinatal immune development on mucosal homeostasis and chronic inflammation Nat Rev Immunol 12 9 23 2011 IF 35 2 62 Renz H von Mutius E Brandtzaeg P Cookson WO Autenrieth IB Haller D Gene environment interactions

    Original URL path: http://www.ugmlc.de/index.php?id=184 (2016-02-17)
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